Open-label PhaseII trial evaluating activity&safety of JDQ443 single-agent as 1st-line treatment for locally advanced or metastatic KRAS G12C-mutant NSLC


Type carcinoma: NSCLC met mutatie
Mutatie: KRAS G12C, STK11
Lijn: 1e
Site: Erasmus MC & Amphia



– Only histology tissue
– No previous systemic treatment for metastatic disease. Prior (neo)adjuvant treatment with chemotherapy and/or immunotherapy, or prior radiotherapy administered sequentially or concomitantly with chemotherapy and/or immunotherapy for localized or locally advanced disease are accepted if the time between therapy completion and enrollment is > 12 months
– ECOG performance status ≤ 1


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An open-label Phase II trial evaluating the activity and safety of JDQ443 single-agent as first-line treatment for patients with locally advanced or metastatic KRAS G12C-mutant non-small cell lung cancer (NSCLC) with a PD-L1 expression <1% or a PD-L1 expression ≥1% and an STK11 co-mutation