A Biomarker-Directed Phase 2 Platform Study in Patients with Advanced Non-Small Cell Lung Cancer whose Disease has Progressed on First-Line Osimertinib Therapy (ORCHARD)
Studiedetails
Type carcinoma: | NSCLC met mutatie |
---|---|
Stadium: | IV |
Mutatie: | EGFR |
Lijn: | 2de na osimertinib |
Site: | Erasmus MC |
Contactgegevens: | long.oncologie@erasmusmc.nl |
Website: | https://-/ |
Inclusiecriteria
Histologically or cytologically confirmed adenocarcinoma of the lung (patients with mixed histology are eligible if adenocarcinoma is the predominant histology) harbouring EGFR mutation(s) known to be associated with EGFR TKI sensitivity at diagnosis.
Received only 1 line of therapy, with single-agent osimertinib, for advanced NSCLC, with clinical benefit as judged by investigator discretion.
WHO 0-1
Exclusiecriteria
Patients whose disease has progressed within the first 3 months of osimertinib treatment (refractory to osimertinib treatment).
Patients should not have discontinued osimertinib >60 days prior to the first dose of study treatment.
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ImmunoSABR
stadium IV - 1ste, 2de of 3de lijn
GENMAB
2de lijn - stadium IV
EVOKE
2de lijns | Stadium III/IV
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Stadium IIIB-IV | Eerstelijns | ROS1 mutation
Ensure
Eerstelijn | Fase I
DeLLphi-304
2e lijns | Stadium III
CUP/EAP/DAP/DRUP
Lijst van verschillende programma's
CARMEN-LC03
2e/3e lijns | Stadium III/IV